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52 kDa GPCR Adrenoceptor Beta 1 Adrenergic Receptor Adrb1r Cell Free Protein

52 kDa GPCR Adrenoceptor Beta 1 Adrenergic Receptor Adrb1r Cell Free Protein
52 kDa GPCR Adrenoceptor Beta 1 Adrenergic Receptor Adrb1r Cell Free Protein

Large Image :  52 kDa GPCR Adrenoceptor Beta 1 Adrenergic Receptor Adrb1r Cell Free Protein

Product Details:

Brand Name: CELLFREE
Model Number: CF-P-001

Payment & Shipping Terms:

Packaging Details: Vial
Delivery Time: 2 weeks
Detailed Product Description
Position: Membrane Protein Type: GPCR
Appearance: Lyophilized Or Liquid MW: 52kDa
Tool: Nanodisc CFPS: E. Coli Extract
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GPCR Cell Free Protein

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52 kDa MW Cell Free Protein

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Adrb1r Cell Free Protein

We supply ADRB1; adrenergic, beta-1-, receptor; beta-1 adrenergic receptor; ADR B1; ADRB 1; ADRB1_HUMAN; ADRB1R; Adrenergic beta 1 receptor; B1AR; Beta 1 adrenoceptor; Beta 1 adrenoreceptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; RHR.

Our Cell-free protein has been Function verificated.

 

Introduction

 

Beta-adrenergic receptors (Beta-1 adrenoreceptor) mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity. Subcellular location cell membrane; Multi-pass membrane protein. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. Belongs to the G-protein coupled receptor 1 family.

Function


The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor binds epinephrine and norepinephrine with approximately equal affinity.

ADRB1 involved in several pathways and played different roles in them. ADRB1 has several biochemical functions, for example, PDZ domain binding, Ras guanyl-nucleotide exchange factor activity, alpha-2A adrenergic receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB1 itself.

 

Subunit


Interacts with GOPC, MAGI3 and DLG4.


Subcellular Location


Cell membrane; Multi-pass membrane protein. Note:Localized at the plasma membrane. Found in the Golgi upon GOPC overexpression.


Post-translational modifications


Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.


Similarity


Belongs to the G-protein coupled receptor 1 family.
Adrenergic receptor subfamily. ADRB1 sub-subfamily.

 

Flow chart

52 kDa GPCR Adrenoceptor Beta 1 Adrenergic Receptor Adrb1r Cell Free Protein 0

 

Advantage of E.Coli system

 

  1. High protein yield
  2. Simple cultivation and fast cell growth and lysate preparation
  3. Cost-efficient
  4. Easy genetic engineering
  5. Well-established

 

For Research Use Only. Not for use in diagnostic procedures

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CELLFREE SCIENCE CO., LTD.

Contact Person: Pan Lin

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